The school friends Paul (Rider Strong), Karen (Jordan Ladd), Bert (James DeBello), Marcy (Cerina Vincent) and Jeff (Joey Kern) rent an isolated cabin in the woods to spend a week together. When they arrive, a man contaminated with a weird disease asks for help to them, but they get in panic and kill the man, who drops dead in the water reservoir. When Karen drinks tap water and gets the disease, the group starts their journey to hell.